In the fifth game of the Bubsy Bobcat franchise entitled Bubsy: The Woolies Strike Back, the Bees are found on the forest levels towards the beginning. As an opponent the bees can be very evasive as they become a part of the background, or merge into the foreground becoming a viable target as they attack. Between the before mentioned phasing back and forth, and quick erratic flight paths make this opponent one of the more difficult in the game to defeat.
However, if you can guide a bee to a flower the bee then joins the flower as a background object, making the bee no longer a threat.